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Truncation or Deglycosylation of the Neuraminidase Stalk Enhances the Pathogenicity of the H5N1 Subtype Avian Influenza Virus in Mallard Ducks

H5N1 subtype avian influenza virus (AIV) with a deletion of 20 amino acids at residues 49–68 in the stalk region of neuraminidase (NA) became a major epidemic virus. To determine the effect of truncation or deglycosylation of the NA stalk on virulence, we used site-directed mutagenesis to insert 20...

詳細記述

保存先:
書誌詳細
出版年:Front Microbiol
主要な著者: Chen, Sujuan, Quan, Keji, Wang, Dandan, Du, Yinping, Qin, Tao, Peng, Daxin, Liu, Xiufan
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641914/
https://ncbi.nlm.nih.gov/pubmed/33193225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.583588
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