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Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data
Somatic hypermutations of immunoglobulin (Ig) genes occurring during affinity maturation drive B-cell receptors’ ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain regions of the Ig gene being preferentially targeted. H...
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| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7641750/ https://ncbi.nlm.nih.gov/pubmed/33035336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa825 |
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