Analysis of a preQ(1)-I riboswitch in effector-free and bound states reveals a metabolite-programmed nucleobase-stacking spine that controls gene regulation

Riboswitches are structured RNA motifs that recognize metabolites to alter the conformations of downstream sequences, leading to gene regulation. To investigate this molecular framework, we determined crystal structures of a preQ(1)-I riboswitch in effector-free and bound states at 2.00 Å and 2.65 Å...

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Foilsithe in:Nucleic Acids Res
Main Authors: Schroeder, Griffin M, Dutta, Debapratim, Cavender, Chapin E, Jenkins, Jermaine L, Pritchett, Elizabeth M, Baker, Cameron D, Ashton, John M, Mathews, David H, Wedekind, Joseph E
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2020
Ábhair:
Structural Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641330/
https://ncbi.nlm.nih.gov/pubmed/32597951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa546
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