Analysis of a preQ(1)-I riboswitch in effector-free and bound states reveals a metabolite-programmed nucleobase-stacking spine that controls gene regulation

Riboswitches are structured RNA motifs that recognize metabolites to alter the conformations of downstream sequences, leading to gene regulation. To investigate this molecular framework, we determined crystal structures of a preQ(1)-I riboswitch in effector-free and bound states at 2.00 Å and 2.65 Å...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Schroeder, Griffin M, Dutta, Debapratim, Cavender, Chapin E, Jenkins, Jermaine L, Pritchett, Elizabeth M, Baker, Cameron D, Ashton, John M, Mathews, David H, Wedekind, Joseph E
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641330/
https://ncbi.nlm.nih.gov/pubmed/32597951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa546
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