Analysis of a preQ(1)-I riboswitch in effector-free and bound states reveals a metabolite-programmed nucleobase-stacking spine that controls gene regulation

Riboswitches are structured RNA motifs that recognize metabolites to alter the conformations of downstream sequences, leading to gene regulation. To investigate this molecular framework, we determined crystal structures of a preQ(1)-I riboswitch in effector-free and bound states at 2.00 Å and 2.65 Å...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Schroeder, Griffin M, Dutta, Debapratim, Cavender, Chapin E, Jenkins, Jermaine L, Pritchett, Elizabeth M, Baker, Cameron D, Ashton, John M, Mathews, David H, Wedekind, Joseph E
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641330/
https://ncbi.nlm.nih.gov/pubmed/32597951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa546
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