Circadian rhythm influences induction of trained immunity by BCG vaccination

BACKGROUND: The antituberculosis vaccine bacillus Calmette-Guérin (BCG) reduces overall infant mortality. Induction of innate immune memory, also termed trained immunity, contributes toward protection against heterologous infections. Since immune cells display oscillations in numbers and function th...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: de Bree, L. Charlotte J., Mourits, Vera P., Koeken, Valerie A.C.M., Moorlag, Simone J.C.F.M., Janssen, Robine, Folkman, Lukas, Barreca, Daniele, Krausgruber, Thomas, Fife-Gernedl, Victoria, Novakovic, Boris, Arts, Rob J.W., Dijkstra, Helga, Lemmers, Heidi, Bock, Christoph, Joosten, Leo A.B., van Crevel, Reinout, Benn, Christine S., Netea, Mihai G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
Schlagworte:
Clinical Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641012/
https://ncbi.nlm.nih.gov/pubmed/32692732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133934
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