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APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease

Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for Alzheimer’s disease (AD), have yielded significant insights into the pathogenic mechanism. Among the three common coding variants, APOE*ε4 increases, whereas APOE*ε2 decreases the risk of late-onset AD compared with...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Li, Zonghua, Shue, Francis, Zhao, Na, Shinohara, Mitsuru, Bu, Guojun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7640652/
https://ncbi.nlm.nih.gov/pubmed/33148290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00413-4
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