Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice

Mir483 is a conserved and highly expressed microRNA in placental mammals, embedded within the Igf2 gene. Its expression is dysregulated in a number of human diseases, including metabolic disorders and certain cancers. Here, we investigate the developmental regulation and function of Mir483 in vivo....

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Publicado no:Cell Rep
Main Authors: Sandovici, Ionel, Fernandez-Twinn, Denise S., Campbell, Niamh, Cooper, Wendy N., Sekita, Yoichi, Zvetkova, Ilona, Ferland-McCollough, David, Prosser, Haydn M., Oyama, Lila M., Pantaleão, Lucas C., Cimadomo, Danilo, de Queiroz, Karina Barbosa, Cheuk, Cecilia S.K., Smith, Nicola M., Kay, Richard G., Antrobus, Robin, Hoelle, Katharina, Ma, Marcella K.L., Smith, Noel H., Geyer, Stefan H., Reissig, Lukas F., Weninger, Wolfgang J., Siddle, Kenneth, Willis, Anne E., Lam, Brian Y.H., Bushell, Martin, Ozanne, Susan E., Constância, Miguel
Formato: Artigo
Idioma:Inglês
Publicado em: 2024
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617298/
https://ncbi.nlm.nih.gov/pubmed/39283743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2024.114750
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