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Nuclear positioning and Xic pairing are not primary determinants during initiation of random X-chromosome inactivation
During X-chromosome inactivation (XCI) one of the two X-inactivation centers (Xic) up-regulates the non-coding Xist RNA to initiate chromosomal silencing in cis. How one Xic is chosen to up-regulate Xist remains unclear. Models proposed include localization of one Xic at the nuclear envelope, or tra...
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| Publicado no: | Nat Genet |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7617203/ https://ncbi.nlm.nih.gov/pubmed/30643252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0305-7 |
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