Leptin-Driven Lipolysis is Mediated by Sympathetic Neuro-Adipose Connections

Leptin is an adipose-derived hormone that acts in the brain to promote fat-breakdown. However, the mechanism underlying the lipolytic effect of leptin has not been established. Here we demonstrate by intra-vital two-photon microscopy that sympathetic nerve fibers can envelop adipocytes. Local optoge...

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Veröffentlicht in:Cell
Hauptverfasser: Zeng, Wenwen, Pirzgalska, Roksana M., Pereira, Mafalda M.A., Kubasova, Nadiya, Barateiro, Andreia, Seixas, Elsa, Lu, Yi-Hsueh, Kozlova, Albina, Voss, Henning, Martins, Gabriel G., Friedman, Jeffrey M., Domingos, Ana I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617198/
https://ncbi.nlm.nih.gov/pubmed/26406372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.08.055
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