A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages

Conditional expression of diphtheria toxin receptor (DTR) is widely used for tissue-specific ablation of cells. However, diphtheria toxin (DT) crosses the blood–brain barrier, which limits its utility for ablating peripheral cells using Cre drivers that are also expressed in the central nervous syst...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pereira, Mafalda M. A., Mahú, Inês, Seixas, Elsa, Martinéz-Sánchez, Noelia, Kubasova, Nadiya, Pirzgalska, Roksana M, Cohen, Paul, Dietrich, Marcelo O, López, Miguel, Bernardes, Gonçalo J. L., Domingos, Ana I.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382263/
https://ncbi.nlm.nih.gov/pubmed/28367972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14967
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