A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages

Conditional expression of diphtheria toxin receptor (DTR) is widely used for tissue-specific ablation of cells. However, diphtheria toxin (DT) crosses the blood–brain barrier, which limits its utility for ablating peripheral cells using Cre drivers that are also expressed in the central nervous syst...

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發表在:Nat Commun
Main Authors: Pereira, Mafalda M. A., Mahú, Inês, Seixas, Elsa, Martinéz-Sánchez, Noelia, Kubasova, Nadiya, Pirzgalska, Roksana M, Cohen, Paul, Dietrich, Marcelo O, López, Miguel, Bernardes, Gonçalo J. L., Domingos, Ana I.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382263/
https://ncbi.nlm.nih.gov/pubmed/28367972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14967
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