Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

The mechanisms of seizure emergence, and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. Our study shows that the transition to seizure is not a sudden phenomenon, but a slow process charac...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Chang, Wei-Chih, Kudlacek, Jan, Hlinka, Jaroslav, Chvojka, Jan, Hadrava, Michal, Kumpost, Vojtech, Powell, Andrew D., Janca, Radek, Maturana, Matias I., Karoly, Philippa J., Freestone, Dean R., Cook, Mark J., Palus, Milan, Otahal, Jakub, Jefferys, John G.R., Jiruska, Premysl
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617160/
https://ncbi.nlm.nih.gov/pubmed/30482946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0278-y
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