Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

The mechanisms of seizure emergence, and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. Our study shows that the transition to seizure is not a sudden phenomenon, but a slow process charac...

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Vydáno v:Nat Neurosci
Hlavní autoři: Chang, Wei-Chih, Kudlacek, Jan, Hlinka, Jaroslav, Chvojka, Jan, Hadrava, Michal, Kumpost, Vojtech, Powell, Andrew D., Janca, Radek, Maturana, Matias I., Karoly, Philippa J., Freestone, Dean R., Cook, Mark J., Palus, Milan, Otahal, Jakub, Jefferys, John G.R., Jiruska, Premysl
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617160/
https://ncbi.nlm.nih.gov/pubmed/30482946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0278-y
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