The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis

BACKGROUND & AIMS: Cancer-associated fibroblasts (CAFs), key constituents of the tumor microenvironment, either promote or restrain tumor growth. Attempts to therapeutically target CAFs have been hampered by our incomplete understanding of these functionally heterogeneous cells. Key growth facto...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Kobayashi, Hiroki, Gieniec, Krystyna A., Wright, Josephine A., Wang, Tongtong, Asai, Naoya, Mizutani, Yasuyuki, Lida, Tadashi, Ando, Ryota, Suzuki, Nobumi, Lannagan, Tamsin R. M., Ng, Jia Q., Hara, Akitoshi, Shiraki, Yukihiro, Mii, Shinji, Ichinose, Mari, Vrbanac, Laura, Lawrence, Matthew J., Sammour, Tarik, Uehara, Kay, Davies, Gareth, Lisowski, Leszek, Alexander, Ian E., Hayakawa, Yoku, Butler, Lisa M., Zannettino, Andrew C. W., Din, M. Omar, Hasty, Jeff, Burt, Alastair D., Leedham, Simon J., Rustgi, Anil K., Mukherjee, Siddhartha, Wang, Timothy C., Enomoto, Atsushi, Takahashi, Masahide, Worthley, Daniel L., Woods, Susan L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617122/
https://ncbi.nlm.nih.gov/pubmed/33197448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.11.011
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