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MEK inhibition reverses aberrant signaling in melanoma cells through reorganization of NRas and BRAF in self nano-clusters

Hotspot mutations of the oncogenes BRAF and NRas are the most common genetic alterations in cutaneous melanoma. Still, the nanoscale organization and signal coupling of these proteins remain incompletely understood, particularly upon expression of oncogenic NRas mutants. Here we employed single-mole...

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Vydáno v:Cancer Res
Hlavní autoři: Yakovian, Oren, Sajman, Julia, Arafeh, Rand, Neve-Oz, Yair, Alon, Michal, Samuels, Yardena, Sherman, Eilon
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617077/
https://ncbi.nlm.nih.gov/pubmed/33355187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1205
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