Leader β cells coordinate Ca(2+) dynamics across pancreatic islets in vivo

Pancreatic β cells form highly connected networks within isolated islets. Whether this behaviour pertains in vivo, after innervation and during continuous perfusion with blood, is unclear. Here, we use the recombinant Ca(2+) sensor GCaMP6 to assess glucose-regulated connectivity in living zebrafish...

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Detalhes bibliográficos
Publicado no:Nat Metab
Main Authors: Salem, Victoria, Silva, Luis Delgadillo, Suba, Kinga, Georgiadou, Eleni, Gharavy, S. Neda Mousavy, Akhtar, Nadeem, Martin-Alonso, Aldara, Gaboriau, David C.A., Rothery, Stephen M., Stylianides, Theodoros, Carrat, Gaelle, Pullen, Timothy J., Singh, Sumeet Pal, Hodson, David J., Leclerc, Isabelle, Shapiro, A.M. James, Marchetti, Piero, Briant, Linford J.B., Distaso, Walter, Ninov, Nikolay, Rutter, Guy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617060/
https://ncbi.nlm.nih.gov/pubmed/32694805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0075-2
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