NMR and EPR reveal a compaction of the RNA-binding protein FUS upon droplet formation

Many RNA-binding proteins undergo liquid-liquid phase separation, which underlies the formation of membrane-less organelles, such as stress granules and P-bodies. Studies of the molecular mechanism of phase separation in vitro is hampered by coalescence and sedimentation of organelle-sized droplets...

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Bibliografske podrobnosti
izdano v:Nat Chem Biol
Main Authors: Emmanouilidis, Leonidas, Esteban-Hofer, Laura, Damberger, Fred F., de Vries, Tebbe, Nguyen, Cristina K. X., Ibáñez, Luis Fábregas, Mergenthal, Simon, Klotzsch, Enrico, Yulikov, Maxim, Jeschke, Gunnar, Allain, Frédéric H.-T.
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617049/
https://ncbi.nlm.nih.gov/pubmed/33686294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-021-00752-3
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