Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs

CRISPR-based diagnostics enable specific sensing of DNA and RNA biomarkers associated with human diseases. This is achieved through the binding of guide RNAs to a complementary sequence which activates Cas enzymes to cleave reporter molecules. Currently, most CRISPR-based diagnostics rely on target...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Nanotechnol
Prif Awduron: Broto, Marta, Kaminski, Michael M., Adrianus, Christopher, Kim, Nayoung, Greensmith, Robert, Dissanayake-Perera, Schan, Schubert, Alexander J., Tan, Xiao, Kim, Hyemin, Dighe, Anand S., Collins, James J., Stevens, Molly M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2022
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616987/
https://ncbi.nlm.nih.gov/pubmed/35927321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41565-022-01179-0
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