Modelling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient

The study of brain development in humans is limited by the lack of tissue samples and suitable in vitro models. Here, we model early human neural tube development using human embryonic stem cells (hESCs) cultured in a microfluidic device. The approach, named microfluidic-controlled stem cell regiona...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Rifes, Pedro, Isaksson, Marc, Rathore, Gaurav Singh, Aldrin-Kirk, Patrick, Møller, Oliver Knights, Barzaghi, Guido, Lee, Julie, Egerod, Kristoffer Lihme, Rausch, Dylan Matthew, Parmar, Malin, Pers, Tune H., Laurell, Thomas, Kirkeby, Agnete
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616963/
https://ncbi.nlm.nih.gov/pubmed/32451506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-0525-0
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