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Intrinsically disordered proteins and biomolecular condensates as drug targets

Intrinsically disordered domains represent attractive therapeutic targets because they play key roles in cancer as well as in neurodegenerative and infectious diseases. They are however considered undruggable because they do not form stable binding pockets for small molecules and therefore have not...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Curr Opin Chem Biol
Main Authors: Biesaga, Mateusz, Frigolé-Vivas, Marta, Salvatella, Xavier
פורמט: Artigo
שפה:Inglês
יצא לאור: 2021
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616887/
https://ncbi.nlm.nih.gov/pubmed/33812316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2021.02.009
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