Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma

Intrinsically disordered proteins (IDPs) are prevalent in eukaryotes, performing signaling and regulatory functions. Often associated with human diseases, they constitute drug-development targets. NUPR1 is a multifunctional IDP, over-expressed and involved in pancreatic ductal adenocarcinoma (PDAC)...

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Udgivet i:Sci Rep
Main Authors: Neira, José L., Bintz, Jennifer, Arruebo, María, Rizzuti, Bruno, Bonacci, Thomas, Vega, Sonia, Lanas, Angel, Velázquez-Campoy, Adrián, Iovanna, Juan L., Abián, Olga
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5213423/
https://ncbi.nlm.nih.gov/pubmed/28054562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39732
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