Guide-independent DNA cleavage by archaeal Argonaute from Methanocaldococcus jannaschii

Prokaryotic Argonaute proteins acquire guide strands derived from invading or mobile genetic elements via an unknown pathway to direct guide-dependent cleavage of foreign DNA. Here, we report that Argonaute from the archaeal organism Methanocaldococcus jannaschii (MjAgo) possesses two modes of actio...

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Udgivet i:Nat Microbiol
Main Authors: Zander, Adrian, Willkomm, Sarah, Ofer, Sapir, van Wolferen, Marleen, Egert, Luisa, Buchmeier, Sabine, Stöckl, Sarah, Tinnefeld, Philip, Schneider, Sabine, Klingl, Andreas, Albers, Sonja-Verena, Werner, Finn, Grohmann, Dina
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616673/
https://ncbi.nlm.nih.gov/pubmed/28319081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmicrobiol.2017.34
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