HIV-1 Nef Promotes Endocytosis of Cell Surface MHC Class II Molecules via a Constitutive Pathway(1)

HIV-1 Nef has been reported to disrupt MHC class II (MHCII)-mediated Ag presentation by a dual strategy that comprises a reduction in cell surface levels of peptide-loaded mature MHCII molecules and a up-regulation of immature MHCII molecules. We show that Nef achieves relocation of MHCII away from...

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Veröffentlicht in:J Immunol
Hauptverfasser: Chaudhry, Ashutosh, Verghese, Divya Anna, Das, Suman Ranjan, Jameel, Shahid, George, Anna, Bal, Vineeta, Mayor, Satyajit, Rath, Satyajit
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616452/
https://ncbi.nlm.nih.gov/pubmed/19620308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804014
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