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HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling
A defining characteristic of HIV-1 infection is the ability of the virus to persist within the host. Specifically, MHC-I downregulation by the HIV-1 accessory protein Nef is of critical importance in preventing infected cells from cytotoxic T-cell mediated killing. Nef downregulates MHC-I by modulat...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5107982/ https://ncbi.nlm.nih.gov/pubmed/27841315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37021 |
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