HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling

A defining characteristic of HIV-1 infection is the ability of the virus to persist within the host. Specifically, MHC-I downregulation by the HIV-1 accessory protein Nef is of critical importance in preventing infected cells from cytotoxic T-cell mediated killing. Nef downregulates MHC-I by modulat...

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Vydáno v:Sci Rep
Hlavní autoři: Dirk, Brennan S., Pawlak, Emily N., Johnson, Aaron L., Van Nynatten, Logan R., Jacob, Rajesh A., Heit, Bryan, Dikeakos, Jimmy D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107982/
https://ncbi.nlm.nih.gov/pubmed/27841315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37021
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