Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis

CCL17 is produced by conventional dendritic cells (cDCs), signals through CCR4 on regulatory T cells (Tregs), and drives atherosclerosis by suppressing Treg functions through yet undefined mechanisms. Here we show that cDCs from CCL17-deficient mice display a pro-tolerogenic phenotype and transcript...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Cardiovasc Res
Egile Nagusiak: Döring, Yvonne, van der Vorst, Emiel P.C., Yan, Yi, Neideck, Carlos, Blanchet, Xavier, Jansen, Yvonne, Kemmerich, Manuela, Bayasgalan, Soyolmaa, Peters, Linsey J.F., Hristov, Michael, Bidzhekov, Kiril, Yin, Changjun, Zhang, Xi, Leberzammer, Julian, Li, Ya, Park, Inhye, Kral, Maria, Nitz, Katrin, Parma, Laura, Gencer, Selin, Habenicht, Andreas, Faussner, Alexander, Teupser, Daniel, Monaco, Claudia, Holdt, Lesca, Megens, Remco T.A., Atzler, Dorothee, Santovito, Donato, von Hundelshausen, Philipp, Weber, Christian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2024
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616283/
https://ncbi.nlm.nih.gov/pubmed/39044999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s44161-023-00413-9
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