Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis

CCL17 is produced by conventional dendritic cells (cDCs), signals through CCR4 on regulatory T cells (Tregs), and drives atherosclerosis by suppressing Treg functions through yet undefined mechanisms. Here we show that cDCs from CCL17-deficient mice display a pro-tolerogenic phenotype and transcript...

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Vydáno v:Nat Cardiovasc Res
Hlavní autoři: Döring, Yvonne, van der Vorst, Emiel P.C., Yan, Yi, Neideck, Carlos, Blanchet, Xavier, Jansen, Yvonne, Kemmerich, Manuela, Bayasgalan, Soyolmaa, Peters, Linsey J.F., Hristov, Michael, Bidzhekov, Kiril, Yin, Changjun, Zhang, Xi, Leberzammer, Julian, Li, Ya, Park, Inhye, Kral, Maria, Nitz, Katrin, Parma, Laura, Gencer, Selin, Habenicht, Andreas, Faussner, Alexander, Teupser, Daniel, Monaco, Claudia, Holdt, Lesca, Megens, Remco T.A., Atzler, Dorothee, Santovito, Donato, von Hundelshausen, Philipp, Weber, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2024
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616283/
https://ncbi.nlm.nih.gov/pubmed/39044999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s44161-023-00413-9
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