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Selecting Invalid Instruments to Improve Mendelian Randomization with Two-Sample Summary Data
Mendelian randomization (MR) is a widely-used method to estimate the causal relationship between a risk factor and disease. A fundamental part of any MR analysis is to choose appropriate genetic variants as instrumental variables. Genome-wide association studies often reveal that hundreds of genetic...
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| Pubblicato in: | Ann Appl Stat |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2024
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7615940/ https://ncbi.nlm.nih.gov/pubmed/38737575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1214/23-AOAS1856 |
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