Regulation of BCR-mediated Ca2+ mobilization by MIZ1-TMBIM4 safeguards IgG1+ GC B cell-positive selection

The heavy chain isotype class confers specific properties to the antibody with critical consequences in infection and vaccination. For a robust class-switched antibody response, IgG1(+) B cells outcompete IgM(+) ones in germinal centers (GCs). Despite this knowledge the molecular mechanisms permitti...

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Vydáno v:Sci Immunol
Hlavní autoři: Zhang, Lingling, Toboso-Navasa, Amparo, Gunawan, Arief, Camara, Abdouramane, Nakagawa, Rinako, Katja, Finsterbusch, Chakravarty, Probir, Newman, Rebecca, Zhang, Yang, Eilers, Martin, Wack, Andreas, Tolar, Pavel, Toellner, Kai-Michael, Calado, Dinis Pedro
Médium: Artigo
Jazyk:Inglês
Vydáno: 2024
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615907/
https://ncbi.nlm.nih.gov/pubmed/38579014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.adk0092
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