Combined Vorinostat and Chloroquine Inhibit Sodium Iodide Symporter Endocytosis and Enhance Radionuclide Uptake In Vivo

PURPOSE: Patients with aggressive thyroid cancer are frequently failed by the central therapy of ablative radioiodide (RAI) uptake, due to reduced plasma membrane (PM) localization of the sodium/iodide symporter (NIS). We aimed to understand how NIS is endocytosed away from the PM of human thyroid c...

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Pubblicato in:Clin Cancer Res
Autori principali: Read, Martin L., Brookes, Katie, Zha, Ling, Manivannan, Selvambigai, Kim, Jana, Kocbiyik, Merve, Fletcher, Alice, Gorvin, Caroline M., Firth, George, Fruhwirth, Gilbert O., Nicola, Juan P., Jhiang, Sissy, Ringel, Matthew D., Campbell, Moray J., Sunassee, Kavitha, Blower, Philip J., Boelaert, Kristien, Nieto, Hannah R., Smith, Vicki E., McCabe, Christopher J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2024
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615786/
https://ncbi.nlm.nih.gov/pubmed/37921808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-23-2043
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