Combined Vorinostat and Chloroquine Inhibit Sodium Iodide Symporter Endocytosis and Enhance Radionuclide Uptake In Vivo

PURPOSE: Patients with aggressive thyroid cancer are frequently failed by the central therapy of ablative radioiodide (RAI) uptake, due to reduced plasma membrane (PM) localization of the sodium/iodide symporter (NIS). We aimed to understand how NIS is endocytosed away from the PM of human thyroid c...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Clin Cancer Res
मुख्य लेखकों: Read, Martin L., Brookes, Katie, Zha, Ling, Manivannan, Selvambigai, Kim, Jana, Kocbiyik, Merve, Fletcher, Alice, Gorvin, Caroline M., Firth, George, Fruhwirth, Gilbert O., Nicola, Juan P., Jhiang, Sissy, Ringel, Matthew D., Campbell, Moray J., Sunassee, Kavitha, Blower, Philip J., Boelaert, Kristien, Nieto, Hannah R., Smith, Vicki E., McCabe, Christopher J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2024
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615786/
https://ncbi.nlm.nih.gov/pubmed/37921808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-23-2043
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