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Perfect adaptation of CD8(+) T cell responses to constant antigen input over a wide range of affinity is overcome by costimulation
Maintaining and limiting T cell responses to constant antigen stimulation is critical to control pathogens and maintain self-tolerance, respectively. Antigen recognition by T cell receptors (TCRs) induces signalling that activates T cells to produce cytokines and also leads to the downregulation of...
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| Udgivet i: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7615691/ https://ncbi.nlm.nih.gov/pubmed/34855472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay9363 |
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