Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose

T cells must respond differently to antigens of varying affinity presented at different doses. Previous attempts to map peptide MHC (pMHC) affinity onto T-cell responses have produced inconsistent patterns of responses, preventing formulations of canonical models of T-cell signaling. Here, a systema...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lever, Melissa, Lim, Hong-Sheng, Kruger, Philipp, Nguyen, John, Trendel, Nicola, Abu-Shah, Enas, Maini, Philip Kumar, van der Merwe, Philip Anton, Dushek, Omer
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087047/
https://ncbi.nlm.nih.gov/pubmed/27702900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608820113
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