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A missense mutation in zinc finger homeobox‐3 (ZFHX3) impedes growth and alters metabolism and hypothalamic gene expression in mice

A protein altering variant in the gene encoding zinc finger homeobox‐3 (ZFHX3) has recently been associated with lower BMI in a human genome‐wide association study. We investigated metabolic parameters in mice harboring a missense mutation in Zfhx3 (Zfhx3 ( Sci/+ )) and looked for altered in situ ex...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Nolan, Patrick M., Banks, Gareth, Bourbia, Nora, Wilcox, Ashleigh G., Bentley, Liz, Moir, Lee, Kent, Lee, Hillier, Rosie, Wilson, Dana, Barrett, Perry, Dumbell, Rebecca
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2023
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615594/
https://ncbi.nlm.nih.gov/pubmed/37713040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202201829R
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