Structure of a ribonucleotide reductase R2 protein radical

Aerobic ribonucleotide reductases (RNRs) initiate synthesis of DNA building blocks by generating a free radical within the R2 subunit; the radical is subsequently shuttled to the catalytic R1 subunit through proton-coupled electron transfer (PCET). We present a high-resolution room temperature struc...

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Pubblicato in:Science
Autori principali: Lebrette, Hugo, Srinivas, Vivek, John, Juliane, Aurelius, Oskar, Kumar, Rohit, Lundin, Daniel, Brewster, Aaron S., Bhowmick, Asmit, Sirohiwal, Abhishek, Kim, In-Sik, Gul, Sheraz, Pham, Cindy, Sutherlin, Kyle D., Simon, Philipp, Butryn, Agata, Aller, Pierre, Orville, Allen M., Fuller, Franklin D., Alonso-Mori, Roberto, Batyuk, Alexander, Sauter, Nicholas K., Yachandra, Vittal K., Yano, Junko, Kaila, Ville R. I., Sjöberg, Britt-Marie, Kern, Jan, Roos, Katarina, Högbom, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2023
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615503/
https://ncbi.nlm.nih.gov/pubmed/37797025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.adh8160
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