Decrypting drug actions and protein modifications by dose- and time-resolved proteomics

Although most cancer drugs modulate the activities of cellular pathways by changing post-translational modifications (PTMs), surprisingly little is known regarding the extent and the time- and dose-response characteristics of drug-regulated PTMs. Here, we introduce a proteomic assay termed decryptM...

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Pubblicato in:Science
Autori principali: Zecha, Jana, Bayer, Florian P., Wiechmann, Svenja, Woortman, Julia, Berner, Nicola, Müller, Julian, Schneider, Annika, Kramer, Karl, Abril-Gil, Mar, Hopf, Thomas, Reichart, Leonie, Chen, Lin, Hansen, Fynn M., Lechner, Severin, Samaras, Patroklos, Eckert, Stephan, Lautenbacher, Ludwig, Reinecke, Maria, Hamood, Firas, Prokofeva, Polina, Vornholz, Larsen, Falcomatà, Chiara, Dorsch, Madeleine, Schröder, Ayla, Venhuizen, Anton, Wilhelm, Stephanie, Médard, Guillaume, Stoehr, Gabriele, Ruland, Jürgen, Grüner, Barbara M., Saur, Dieter, Buchner, Maike, Ruprecht, Benjamin, Hahne, Hannes, The, Matthew, Wilhelm, Mathias, Kuster, Bernhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2023
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615311/
https://ncbi.nlm.nih.gov/pubmed/36926954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.ade3925
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