Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress

Traditionally viewed as poorly plastic, neutrophils are now recognized as functionally diverse. However, the extent and determinants of neutrophil heterogeneity in humans remain unclear. We performed a comprehensive immunophenotypic and transcriptome analysis, at bulk and single-cell level, of neutr...

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Veröffentlicht in:Nat Immunol
Hauptverfasser: Montaldo, Elisa, Lusito, Eleonora, Bianchessi, Valentina, Caronni, Nicoletta, Scala, Serena, Basso-Ricci, Luca, Cantaffa, Carla, Masserdotti, Alice, Barilaro, Mattia, Barresi, Simona, Genua, Marco, Vittoria, Francesco Maria, Barbiera, Giulia, Lazarevic, Dejan, Messina, Carlo, Xue, Elisabetta, Marktel, Sarah, Tresoldi, Cristina, Milani, Raffaella, Ronchi, Paola, Gattillo, Salvatore, Santoleri, Luca, Di Micco, Raffaella, Ditadi, Andrea, Belfiori, Giulio, Aleotti, Francesca, Naldini, Matteo Maria, Gentner, Bernhard, Gardiman, Elisa, Tamassia, Nicola, Cassatella, Marco Antonio, Hidalgo, Andrés, Kwok, Immanuel, Ng, Lai Guan, Crippa, Stefano, Falconi, Massimo, Pettinella, Francesca, Scapini, Patrizia, Naldini, Luigi, Ciceri, Fabio, Aiuti, Alessandro, Ostuni, Renato
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2022
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615267/
https://ncbi.nlm.nih.gov/pubmed/36138183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-022-01311-1
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