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Alzheimer’s genetic risk effects on cerebral blood flow across the lifespan are proximal to gene expression

Cerebrovascular dysregulation such as altered cerebral blood flow (CBF) can be observed in Alzheimer’s disease (AD) and may precede symptom onset. Genome wide association studies show that AD has a polygenic aetiology, providing a tool for studying AD susceptibility across the lifespan. Here, we asc...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Chandler, Hannah, Wise, Richard, Linden, David, Williams, Julie, Murphy, Kevin, Lancaster, Thomas Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615143/
https://ncbi.nlm.nih.gov/pubmed/36070676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2022.08.001
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