Polygenic impact of common genetic risk loci for Alzheimer’s disease on cerebral blood flow in young individuals

Genome-wide association studies (GWAS) show that many common alleles confer risk for developing Alzheimer’s disease (AD). These risk loci may contribute to MRI alterations in young individuals, preceding the clinical manifestations of AD. Prior evidence identifies vascular dysregulation as the earli...

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Vydáno v:Sci Rep
Hlavní autoři: Chandler, Hannah L., Wise, Richard G., Murphy, Kevin, Tansey, Katherine E., Linden, David E. J., Lancaster, Thomas M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345995/
https://ncbi.nlm.nih.gov/pubmed/30679549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36820-3
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