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Structural basis of branch site recognition by the human spliceosome
Recognition of the intron branch site (BS) by the U2 snRNP is a critical event during spliceosome assembly. In mammals, BS sequences are poorly conserved and unambiguous intron recognition cannot be achieved solely via a base-pairing mechanism. We isolated human 17S U2 snRNP and reconstituted in vit...
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| Gepubliceerd in: | Science |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2022
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7614990/ https://ncbi.nlm.nih.gov/pubmed/34822310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abm4245 |
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