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Structural basis of branch site recognition by the human spliceosome

Recognition of the intron branch site (BS) by the U2 snRNP is a critical event during spliceosome assembly. In mammals, BS sequences are poorly conserved and unambiguous intron recognition cannot be achieved solely via a base-pairing mechanism. We isolated human 17S U2 snRNP and reconstituted in vit...

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Bibliografische gegevens
Gepubliceerd in:Science
Hoofdauteurs: Tholen, Jonas, Razew, Michal, Weis, Felix, Galej, Wojciech P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2022
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614990/
https://ncbi.nlm.nih.gov/pubmed/34822310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abm4245
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