Targeted GATA3 knockdown in activated T Cells via pulmonary siRNA delivery as novel therapy for allergic asthma

GATA3 gene silencing in activated T cells displays a promising option to early-on undermine pathological pathways in the disease formation of allergic asthma. The central transcription factor of T helper 2 (Th2) cell cytokines IL-4, IL-5, and IL-13 plays a major role in immune and inflammatory casca...

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Bibliografske podrobnosti
izdano v:J Control Release
Main Authors: Kandil, Rima, Baldassi, Domizia, Böhlen, Sebastian, Müller, Joschka T., Keul, David C., Bargmann, Tonia, Dehmel, Susann, Xie, Yuran, Mehta, Aditi, Sewald, Katherina, Merkel, Olivia M.
Format: Artigo
Jezik:Inglês
Izdano: 2023
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614985/
https://ncbi.nlm.nih.gov/pubmed/36634709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2023.01.014
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