Super-resolution imaging unveils the self-replication of tau aggregates upon seeding

Tau is a soluble protein interacting with tubulin to stabilize microtubules. However, under pathological conditions, it becomes hyperphosphorylated and aggregates, a process that can be induced by treating cells with exogenously added tau fibrils. Here, we employ single-molecule localization microsc...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Dimou, Eleni, Katsinelos, Taxiarchis, Meisl, Georg, Tuck, Benjamin J., Keeling, Sophie, Smith, Annabel E., Hidari, Eric, Lam, Jeff Y.L., Burke, Melanie, Lövestam, Sofia, Ranasinghe, Rohan T., McEwan, William A., Klenerman, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2023
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614924/
https://ncbi.nlm.nih.gov/pubmed/37393617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2023.112725
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