Molecular mimicry of NF-κB by vaccinia virus protein enables selective inhibition of antiviral responses

Infection of mammalian cells with viruses activates NF-κB to induce the expression of cytokines and chemokines and initiate an antiviral response. Here, we show that a vaccinia virus protein mimics the transactivation domain of the p65 subunit of NF-κB to inhibit selectively the expression of NF-κB-...

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Pubblicato in:Nat Microbiol
Autori principali: Albarnaz, Jonas D., Ren, Hongwei, Torres, Alice A., Shmeleva, Evgeniya V., Melo, Carlos A., Bannister, Andrew J., Brember, Matthew P., Chung, Betty Y-W., Smith, Geoffrey L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2022
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614822/
https://ncbi.nlm.nih.gov/pubmed/34949827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-021-01004-9
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