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Mass spectrometry enables the discovery of inhibitors of an LPS transport assembly via disruption of protein–protein interactions†
We developed a native mass spectrometry-based approach to quantify the monomer–dimer equilibrium of the LPS transport protein LptH. We use this method to assess the potency and efficacy of an antimicrobial peptide and small molecule disruptors, obtaining new information on their structure–activity r...
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| Publicado no: | Chem Commun (Camb) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7614387/ https://ncbi.nlm.nih.gov/pubmed/34585198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1cc04186j |
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