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Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression

Poly(A) tails, present on almost every eukaryotic mRNA, were discovered over 50 years ago. Early experiments led to the hypothesis that poly(A) tails and the cytoplasmic poly(A)-binding protein promote translation and prevent mRNA degradation, but the details remained unclear. More recent data sugge...

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Bibliografiska uppgifter
I publikationen:Nat Rev Mol Cell Biol
Huvudupphovsmän: Passmore, Lori A, Coller, Jeff
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2022
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614307/
https://ncbi.nlm.nih.gov/pubmed/34594027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41580-021-00417-y
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