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Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression

Poly(A) tails, present on almost every eukaryotic mRNA, were discovered over 50 years ago. Early experiments led to the hypothesis that poly(A) tails and the cytoplasmic poly(A)-binding protein promote translation and prevent mRNA degradation, but the details remained unclear. More recent data sugge...

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Detalhes bibliográficos
Publicado no:Nat Rev Mol Cell Biol
Main Authors: Passmore, Lori A, Coller, Jeff
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614307/
https://ncbi.nlm.nih.gov/pubmed/34594027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41580-021-00417-y
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