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Structural Basis of Mammalian Respiratory Complex I Inhibition by Medicinal Biguanides
The molecular mode of action of metformin, a biguanide used widely in the treatment of diabetes, is incompletely characterized. Here we define the inhibitory drug-target interaction(s) of a model biguanide with mammalian respiratory complex I by combining cryo-electron microscopy and enzyme kinetics...
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| Pubblicato in: | Science |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2023
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7614227/ https://ncbi.nlm.nih.gov/pubmed/36701435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.ade3332 |
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