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Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase
BACKGROUND: The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic biguanide, also inhibits respiration, but pro...
Gorde:
| Argitaratua izan da: | BMC Biol |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
BioMed Central
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4977651/ https://ncbi.nlm.nih.gov/pubmed/27506389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-016-0287-9 |
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