Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes

Precise control of activating H3K4me3 and repressive H3K27me3 histone modifications at bivalent promoters is essential for normal development and is frequently corrupted in cancer. By coupling a cell surface readout of bivalent MHC class I gene expression with whole genome CRISPR/Cas9 screens, we id...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Sparbier, Christina E., Gillespie, Andrea, Gomez, Juliana, Kumari, Nishi, Motazedian, Ali, Chan, Kah Lok, Bell, Charles C., Gilan, Omer, Chan, Yih-Chih, Popp, Sarah, Gough, Daniel J., Eckersley-Maslin, Melanie A., Dawson, Sarah-Jane, Lehner, Paul J., Sutherland, Kate D., Ernst, Patricia, McGeehan, Gerard M., Lam, Enid Y. N., Burr, Marian L., Dawson, Mark A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2023
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614190/
https://ncbi.nlm.nih.gov/pubmed/36635503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-022-01056-x
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