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Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape
Statistical mechanics can describe the major conformational ensembles determining the equilibrium free-energy landscape of a folding protein. The challenge is to capture the full repertoire of low-occurrence conformations separated by high kinetic barriers that define complex landscapes. Computation...
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| 出版年: | Nat Phys |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2023
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7614079/ https://ncbi.nlm.nih.gov/pubmed/36660164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41567-022-01808-4 |
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