Mechanical stress driven by rigidity sensing governs epithelial stability

Epithelia act as a barrier against environmental stress and abrasion and in vivo they are continuously exposed to environments of various mechanical properties. The impact of this environment on epithelial integrity remains elusive. By culturing epithelial cells on 2D hydrogels, we observe a loss of...

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Gepubliceerd in:Nat Phys
Hoofdauteurs: Sonam, Surabhi, Balasubramaniam, Lakshmi, Lin, Shao-Zhen, Ivan, Ying Ming Yow, Jaumà, Irina Pi, Jebane, Cecile, Karnat, Marc, Toyama, Yusuke, Marcq, Philippe, Prost, Jacques, Mège, René-Marc, Rupprecht, Jean-François, Ladoux, Benoît
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2023
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614076/
https://ncbi.nlm.nih.gov/pubmed/36686215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41567-022-01826-2
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