Inhibiting ERK5 Overcomes Breast Cancer Resistance to Anti-HER2 Therapy By Targeting the G(1)–S Cell-Cycle Transition

Targeting HER2 has become a landmark in the treatment of HER2-driven breast cancer. Nonetheless, the clinical efficacy of anti-HER2 therapies can be short-lived and a significant proportion of patients ultimately develop metastatic disease and die. One striking consequence of oncogenic activation of...

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Vydáno v:Cancer Res Commun
Hlavní autoři: Zhang, Jingwei, Pearson, Adam J., Sabherwal, Nitin, Telfer, Brian A., Ali, Nisha, Kan, Karmern, Xu, Qiuping, Zhang, Wei, Chen, Fuhui, Li, Shiyang, Wang, Jinhua, Gray, Nathanael S., Risa-Ebrí, Blanca, Finegan, Katherine G., Cross, Michael J., Giurisato, Emanuele, Whitmarsh, Alan J., Tournier, Cathy
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for Cancer Research 2022
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613885/
https://ncbi.nlm.nih.gov/pubmed/36466034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2767-9764.CRC-21-0089
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