GnRH replacement rescues cognition in Down Syndrome

Currently, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive non-reproductive neurological symptoms closely parallel a post-pubertal decrease in hypothalamic as well as extra-hypothalamic expression of a...

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出版年:Science
主要な著者: Manfredi-Lozano, Maria, Leysen, Valerie, Adamo, Michela, Paiva, Isabel, Rovera, Renaud, Pignat, Jean-Michel, Timzoura, Fatima Ezzahra, Candlish, Michael, Eddarkaoui, Sabiha, Malone, Samuel A., Silva, Mauro S. B., Trova, Sara, Imbernon, Monica, Decoster, Laurine, Cotellessa, Ludovica, Tena-Sempere, Manuel, Claret, Marc, Paoloni-Giacobino, Ariane, Plassard, Damien, Paccou, Emmanuelle, Vionnet, Nathalie, Acierno, James, Maceski, Aleksandra Maleska, Lutti, Antoine, Pfrieger, Frank, Rasika, S., Santoni, Federico, Boehm, Ulrich, Ciofi, Philippe, Buée, Luc, Haddjeri, Nasser, Boutillier, Anne-Laurence, Kuhle, Jens, Messina, Andrea, Draganski, Bogdan, Giacobini, Paolo, Pitteloud, Nelly, Prevot, Vincent
フォーマット: Artigo
言語:Inglês
出版事項: 2022
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613827/
https://ncbi.nlm.nih.gov/pubmed/36048943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abq4515
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