Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal center imprinting

Memory B cells (MBCs) can persist for a lifetime, but the mechanisms that allow their long-term survival remain poorly understood. Here, we isolated and analyzed human splenic smallpox/vaccinia protein B5-specific MBCs in individuals who were vaccinated more than 40 years ago. Only a handful of clon...

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Détails bibliographiques
Publié dans:Immunity
Auteurs principaux: Chappert, Pascal, Huetz, François, Espinasse, Marie-Alix, Chatonnet, Fabrice, Pannetier, Louise, Silva, Lucie Da, Goetz, Clara, Mégret, Jérome, Sokal, Aurélien, Crickx, Etienne, Nemazanyy, Ivan, Jung, Vincent, Guerrera, Chiara, Storck, Sébastien, Mahévas, Matthieu, Cosma, Antonio, Revy, Patrick, Fest, Thierry, Reynaud, Claude-Agnès, Weill, Jean-Claude
Format: Artigo
Langue:Inglês
Publié: 2022
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613742/
https://ncbi.nlm.nih.gov/pubmed/36130603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2022.08.019
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